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Description
Collagen production naturally decreases by about 1% per year after age 25
Change history 11 January 2026 "The original online version of this article was revised: the figures and supplementary Information have been updated
Hormonal disorders: Hormonal imbalances due to thyroid disorders, polycystic ovary syndrome, and insulin resistance can trigger melanin production
Statements Author contributions GM: Writing original draft, Writing review & editing
10.1016/S1473-3099(02)00347-X
These changes collectively trigger neuroinflammation via hematogenous and vagal pathways
