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In an autopsy cohort of 700 middle-aged Finnish men, the HL C-480T promoter polymorphism was related to a larger coronary atherosclerotic plaque area [21], and in a large population-based Danish study homozygosity for three common single nucleotide polymorphisms in the HL promoter (216A, 480T, and 729G) was associated with an increased risk of ischemic heart disease despite higher plasma HDL cholesterol [22]

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Sampath AJ, Ruffolo AM, Miedema J, Googe PB, Thomas NE

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Pharmacology of valproic acid VPA potentiates -aminobutyric acid (GABA)ergic functions in some specific brain regions that are thought to be involved in the control of seizure generation and propagation by increasing both GABA synthesis and release [8]

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