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Similarly, a further study revealed that heat acclimation in mice necessitates preoptic BDNF neurons and postsynaptic potentiation ( In conclusion, WSNs possess significant potential in the prevention and treatment of heatstroke, and their distinctive biological characteristics and roles facilitate the development of innovative therapeutic approaches

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Of note, plasminogen levels were negatively associated with the number of failed organs and were lower in patients with cerebral and coagulation failure, suggesting plasminogen as an independent prognostic factor