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doi: 10.1128/msystems.00001-18 [DOI] [PMC free article] [PubMed] [Google Scholar] 88.Dhamdhere G, Krishnamoorthy G, Zgurskaya HI

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doi: 10.1007/s00213-012-2837-3

APC acts as a gatekeeper gene, initiating adenoma formation when mutated

Although these dermatological changes are not life-threatening, they frequently contribute to significant psychosocial distress and have been associated with systemic inflammatory activation (70)

The activity of the mitochondrial enzyme, glycine decarboxylase (GDC), is sensitive to oxidative stress (Taylor et al., 2002), and this enzyme has recently been shown to be inhibited by thiol modifications on several cysteine residues (Palmieri et al., 2010)