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Association between metformin and vitamin B(12) deficiency in patients with type 2 diabetes: A systematic review and meta-analysis

The strongest published finding is from the foundational Biochemical Pharmacology study by Neelakantan et al.: in diet-induced obese mice, daily 5-Amino-1MQ administration produced reductions in body weight, white adipose tissue mass, and adipocyte size without any significant change in food intake

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This remains the only human clinical data for a MOTS-c-based compound

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