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The inflammatory response initially involves the acute phase response (APR), which describes how the body responds to any tissue damage and infection through a series of specific physiological reactions in its attempt to repair the damage caused by offending organisms, promote wound healing, and recruit host defense mechanisms, including the innate immune response (Black, 2003)

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doi: 10.1007/s00425-002-0944-9

In this case, we are delivering siRNA only to melanoma cells in the lung via a targeting ligand specific for the sigma receptor, which will allow endocytosis of and siRNA delivery from the liposome

[DOI] [PubMed] [Google Scholar] 39.Itoh T, Obata H, Murakami S, Hamada K, Kangawa K, Kimura H, Nagaya N