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According to their role during endochondral ossification, hypertrophic chondrocytes in OA cartilage not only express high levels of collagen type 10, but also catabolic (i.e., ADAMTS5 and MMP-13), pro-inflammatory (i.e., CXCL1 and IL-8), and ossification-related markers (i.e., RUNX2 and alkaline phosphatase) [123]

doi: 10.1016/j.conb.2015.12.004
In the morning, follow with a broad-spectrum sunscreen

About this article Cite this article Oft, H.C., Simon, D.W

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