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(160) proposed the KD as metabolic stress that would cause a decrease in the enzyme adenosine kinase, an inhibitory regulator of adenosine, inducing its increase in the cell and activating its receptors, causing a tonic inhibition of presynaptic and postsynaptic neurons through the adenosine receptor 1 (RA1) and conferring a protective effect against epileptic seizures

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doi: 10.1016/j.neuron.2016.03.038

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