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Oxidative stress upregulates the MMP-9 expression while Trx inhibits MMP-9 via its antioxidant properties

doi: 10.1074/jbc.AC120.012571 86 EthertonMFldyCSharmaMTabuchiKLiuXShamlooMet al

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Resveratrol, a potent SIRT1 activator, promotes cell survival by regulating SIRT1-dependent p53 deacetylation (Howitz et al., 2003

A key concern is the safety and potential side effects of long-term use of these supplements

they are summarised here for the benefit of researchers designing in-vitro or animal studies
