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PLoS One 11(1):e0147469

One of the key contributors to aging is oxidative stress, which glutathione neutralizes

However, gentamicin is known to behave as a prooxidant enhancing the formation of hydroxyl radicals, superoxide anion radicals, and hydrogen peroxide (Galaly et al

(6) mutation in drug targets or feedback activation of other targets and signaling pathways [38]

Not only was the regulation of the two step glutathione-synthetic pathway unevenly regulated, but the oxidation/reduction cycle of GSH/GSSG was also unbalanced in infested resistant plants

Kretzschmar M. Regulation of hepatic glutathione metabolism and its role in hepatotoxicity. Experimental and Toxicologic Pathology. 1996;48: 439446. doi:10.1016/S0940-2993(96)80054-6
