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Focused clinical trials on the clinical efficacy of parenteral GLN supplementation combined with adequate and complete specialized nutrition support are needed in critically ill patients at risk of GLN depletion who do not have multiple organ failure or ongoing shock

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These patterns suggest modest but coordinated metabolite-level responses to dietary intervention rather than a global metabolic shift

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Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

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10.3389/fcell.2020.600950

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