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Our clinicians need reminding that Pernicious anaemia (PA) is the very tip of a huge iceberg

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But at higher doses like 5mg per week, that same vial lasts only two weeks, meaning nearly half the reconstituted solution never gets used before the 28-day limit if you are only at the start of your protocol

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,

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The timeline does not support this mechanism

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The potential influence of the FCGR3A F158V polymorphism, which affects FcRs binding to the Fc fragment of antibodies and is more prevalent among patients with MM and MGUS, remains to be investigated ( 2.2.1 Neonatal IgG Fc receptor The Neonatal IgG Fc Receptor (FcRn) was characterized years ago from maternal milk

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