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Pentameric nCRP does not possess intrinsic proinflammatory properties, while nnCRP and mCRP do (170, 196)
DOI: 10.1001/jama.2020.4783 Kissler SM et al
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van Os J, Kenis G, Rutten BPF

Meanwhile, as noted above, targeted neurological effects may best be achieved with nasal sprays
Mao, F.-y et al