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ATH-1017 is a subcutaneously delivered small molecule drug that can cross the blood-brain barrier

doi: 10.1093/jnci/djv077 146 AndradasCBlasco-BenitoSCastillo-LluvaSDillenburg-PillaPDiez-AlarciaRJuanes-GarcaAet al
Inhibition of chymotrypsin through surface binding using nanoparticle-based receptors

This method breaks the filling into large pieces, significantly reducing mercury vaporization compared to conventional drilling
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