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The progressive degeneration or dysfunction of RPE cells, which is a hallmark of multiple retinal disorders, invariably causes vision loss or even permanent blindness due to the absence of regenerative capacity (80) ( Table 1 )

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The method of claim 8, wherein reacting an aliphatic polyol having at least three OH functional groups with a nitrating solution comprising sulfuric acid and at least one of ammonium nitrate and a metal nitrate comprises adding the aliphatic polyol to the nitrating solution at a temperature of less than about 80 C

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism

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