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1.2 Concept of macrophage polarization Macrophage polarization is a plasticity process in which these cells adopt distinct functional states upon microenvironmental signals and it plays a central role in maintaining tissue homeostasis and driving disease progression ( However, the traditional M1/M2 dichotomy oversimplifies the functional continuum of macrophages in complex biological environments

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The presence of hydroxyl and amine groups is crucial for the biological activity of many coumarins

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