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Probiotics like Lactobacillus plantarum ZDY01 and ZDY04 have demonstrated TMAO-lowering effects ( 4.3 Related intermediate inhibitors In TMAO metabolism, CutC/D & FMO3 are crucial

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Specific nutrients with the strongest cardiovascular evidence include omega-3 fatty acids, which reduce triglycerides and inflammation, soluble fibre from oats, barley, chia seeds, legumes, certain vegetables and fruit, which reduces LDL cholesterol, potassium from vegetables and fruit, which supports healthy blood pressure, and extra virgin olive oil for its anti-inflammatory properties

Nutraceuticals as therapeutic agents for atherosclerosis

doi: 10.1111/j.1528-1167.2005.00705.x

Specifically, humans with HFpEF have also been shown to have diminished microbiome diversity [52, 53] but it remains to be elucidated whether this is a trigger of HFpEF or collateral damage [14]