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However, the emergence of drug-resistant strains in some individuals remains a major challenge, reducing overall cART efficacy and warranting the need for novel therapeutic strategies

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243 In AML, the level of H3K36me3 changes most dramatically before and after Met deprivation, and inhibition of STED2, the H3K36-specific methyltransferase, can reproduce most of the cytotoxic phenotypes produced by Met deprivation

no NDA has been filed for monotherapy at this time
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