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5 Therapeutic options and limitations As shown in Figure 2, various therapeutic options have been considered in melasma management (Goel and Trivedi, 2023
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All studies found ALA to be a safe and tolerable intervention
Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis
Notably, application of C@PA(+) significantly reduced GPX activity compared to the control group, indicating that RS impaired GPX activity, which was reversed by SeC@PA
