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Exact figures for PA are difficult due to inconsistent diagnostic thresholds, imperfect tests, and under-recognition

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From a therapeutic perspective, the central role of GPX4 is not equivalent to the only critical node

The reaction was incubated at 42C to be incubated with 30 min after which it was incubated at 95C to destroy the enzyme after 5 min

Reconstituted material should be stored only under controlled conditions appropriate for short-term analytical use

This research was supported by grants from the National Natural Science Foundation of China (32388101 and 32250001 to D.X., 32425011 and 32488302 to J.Y.), National Key R&D Program of China (2022YFD1400800 and 2021YFA1300400 to D.X.), China Postdoctoral Science Foundation (2020M670286 to Y.Y.), Postdoctoral Fellowship of Tsinghua-Peking Joint Center for Life Sciences