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While these early results are encouraging, most of the data comes from in-vitro experiments (in test tubes) or small, short-term trials
New York, NY: McGraw-Hill Education
During darkness, melatonin is rhythmically produced by the pineal glandconcentrations peak between the hours of 2 a.m
Importantly, during nasal delivery, a large proportion of the drug enters the brain via the neuronal route, and therefore, a nonsignificant part may also enter the systemic circulation [141]
