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9 In addition, the redox potentials of the mitochondrial and cytosolic NADP(H) systems are the same around400 mV in the liver

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For example, HepG2 cells exposed to 20 mM APAP for 24 h showed only a minor (8%) reduction in GSH content, a minor increase in protein adducts, no mitochondrial dysfunction and only a 2-fold increase in lactate dehydrogenase (LDH) release [142]

If these pathways are lacking the required vitamins and minerals, dangerous homocysteine levels and potential ill health can result

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