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[65] In addition to substrate binding sites, the enzyme has several binding sites for allosteric effectors

139 The causal relationship between use of acetaminophen and the occurrence of asthma has been questioned, 140 but the consensus is that a relationship exists 141,142 and a population-wide increase in asthma of more than 40% may be caused by the use of acetaminophen

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Additionally, in a mouse model of permanent middle cerebral artery occlusion-induced cerebral ischemia, mice lacking CP exhibit an increased area of cerebral infarction, leading to more severe oxidative stress damage to lipids and proteins (Ryan et al., 2019)