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Umbilicalcord biomarker studies have reported that higher unmetabolized acetaminophen and OS markers (e.g., 8hydroxydeoxyguanosine) coexist in some exposed pregnancies, supporting a biologically coherent stress pathway in susceptible dyads (Anand et al., 2021[4]

Mechanisms of OR desensitization OR phosphorylation Numerous studies have been carried out to demonstrate the role of OR phosphorylation in desensitization by using chemical inhibitors of kinases, in vitro or in vivo knock-out (KO) of kinases using siRNA or transgenic mice, over-expression of dominant negative mutants of kinases, amino acid substitution or truncation on OR

Focus on molecules: the cystine/glutamate exchanger (System x(c)(-))

Psychiatry 80, e71e72 [DOI] [PubMed] [Google Scholar]

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Additionally, disturbances in autophagy-lysosome degradation process, where the assembly of ATPases was interrupted and the lysosome in RPE cells was alkalinized, led to the digestion of ACSL4 protein, and ultimately to ferroptosis (91)