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Peptides discussed in this article don't cause chemical dependency or addiction in the classical sense

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In Gclc -KO liver, the GSH level is less than 5%, but in Chac1 -overexpression mice, the liver GSH level is approximately 15%, which is sufficient to maintain normal liver function and mitochondrial respiration (14)

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Clinical dose ranges for the other seven active ingredients weren't included in the materials available for this review, so no direct numeric comparison is made for NR, NMNH, CoQ10, NAC, Vitamin C, Hyaluronic Acid, or Mulberry Extract - but the same principle applies: cited research generally used oral administration at levels not confirmed to match what's in this patch

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