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Description

HDGF is a secretory heparin-binding growth factor purified from conditioned medium in which a human hepatoma cell line (HuH-7) was cultured (25) and involved in tumour-associated events such as tumourigenesis, metastasis and angiogenesis (18)

Peer review Peer review information Nature Reviews Nephrology thanks David Ellison, Daniel Fuster, Ewout Hoorn and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Yoshimura K, Tsukamoto K, Okazaki M, et al

B12 is a vitamin that plays a crucial role in cognitive and nervous system functions

Therefore, Iva might have beneficial effects on neurological disorders linked to HCN channelopathies
