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Renal function: Dehydration secondary to gastrointestinal side effects can impair renal function, particularly in those with pre-existing kidney disease

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It usually develops slowly over a number of years and causes weak and fragile bones that break easily, even after minor falls

Chen YF, Li PL, Zou AP: Oxidative stress enhances the production and actions of adenosine in the kidney

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[DOI] [PMC free article] [PubMed] [Google Scholar] 316.Dollerup, O