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TLR4 is a critical regulator of angiotensin II-induced vascular remodeling: the roles of extracellular SOD and NADPH oxidase
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Enzymatic activities also play a critical role in modulating the levels of free radicals in the body [59]
R.ProgidaC.De NittoE.GaballoA.et al
Moreover, overproduction of ROS has an impact to enhance the cancer cell proliferation, migration, metastasis, invasiveness and poor prognosis through many cellular mechanisms like matrix degradation, cell-cell contact, cell remodelling, as well as regulation of gene expression [54]
doi: 10.1152/physrev.00019.2012 112 LuuMWeigandKWediFBreidenbendCLeisterHPautzSet al
