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Strategies to minimize plant and medication-induced nephrotoxicity include quality control and standardization of herbal/drug products, research on the pathophysiological mechanisms of toxicity and adequate clinical trials to demonstrate efficacy and safety [56]

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Terpenes like limonene and menthol are recognised for their ability to alter the lipid organisation of the stratum corneum, generating microvoids that facilitate the passage of liposomes [286]

Life expectancy in the DS population is shorter compared with non-DS individuals, but improvements in medical care and drug treatments have significantly contributed to ameliorate the quality of life of people with DS (458)

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