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Over days and weeks, these fluctuations stress the peptide structure and can reduce potency faster than the BUD anticipates

Systemic side effects are rare but can include mild nausea or headache if the dose is too high

This review integrates current mechanistic insights with orthopaedic relevance, emphasizing safety, efficacy, and future directions for responsible integration into musculoskeletal care

Supported in animals for MOTS-c specifically [2]

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