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A study of 350 healthy, reproductiveage women using etonogestrel implants for 1236 months were genotyped for 14 genes encoding proteins involved in steroid hormonerelated pathways.60 Carriers of the CYP3A7*1C allele were more likely to have serum etonogestrel concentrations falling below the threshold of 90 pg/mL required for consistent ovulatory suppression

Unlike hormonal compounds, discontinuation simply means return to baseline rather than below-baseline function

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