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This was associated with reduced expression of xCT (the catalytic subunit of Sxc ) and mGlu2 receptors [116], suggesting that a defective endogenous activation of mGlu2 receptors in the nucleus accumbens underlies the altered glutamate homeostasis that is ultimately responsible for the loss of control in drug-seeking behavior and relapse

How Glutathione Works Glutathione's primary mode of action is as a reducing agent, meaning it donates electrons to unstable moleculesfree radicalsto neutralize them

Proc R Soc Lond B 272:877886 Bnhegyi G, Csala M, Braun L, Garz T, Mandl J (1996) Ascorbate synthesis-dependent glutathione consumption in mouse liver

Singh RK, Lee KM, Vujkovic-Cvijin I, Ucmak D, Farahnik B, Abrouk M

[DOI] [PMC free article] [PubMed] [Google Scholar] 111.Grosse C., Grass G., Anton A., Franke S., Santos A.N., Lawley B., Brown N.L., Nies D.H