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Interestingly, in tumorigenesis these enzymes protect from cancer development but once this fails GSTs are essential for ensuring the survival of tumor cells [91]

Yuan et al

Disulfide bond-disrupting agents activate the tumor necrosis family-related apoptosis-inducing ligand/death receptor 5 pathway

doi: 10.3390/genes11060691 63

GABA release in DA neurons is dependent on the GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 and decreased it leads to increased alcohol consumption and preference (93)

These intracellular events are dynamically coupled with intercellular communication and microenvironment remodeling to jointly promote DTP survival and further tumor progression