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It makes protocol design more important, not less

1199 Pioglitazone, a PPAR agonist, promotes the functional expansion of dendritic cells in SLE patients by activating AMPK and inhibiting the mTOR1 signaling pathway

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Formulations were further evaluated in a phase IIa study [15], in patients with CAH to compare the steady-state serum concentration profiles and pharmacodynamic responses relative to immediate-release hydrocortisone (Cortef , Pfizer, USA)

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