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Serum methylmalonic acid and holotranscobalamin-II as markers for vitamin B 12 deficiency in end-stage renal disease patientsAnn Clin Lab Sci2013;43:243-9.pmid:23884217Abstract/FREE Full TextGoogle Scholar Kim J, Kim H, Roh H, Kwon Y

The dose needed depends on how bad the deficiency is, your age, and your health

Within 24 to 48 hours : For others, it may take a day or two to notice a difference

Improved Cognitive Function and Mood B12 is essential for maintaining healthy nerve cells and producing neurotransmitters that regulate mood

Expected results and timeline Managing expectations prevents disappointment