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Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC)

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Our review identifies three cases of exclusive oral therapy [7, 8, 39, 40] and two combinationroute [9, 41] cases with hematological improvement

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This study further demonstrates that PHB2 S91/S176 phosphorylation dynamically regulates mitochondrial ER autophagy coordination, metabolic homeostasis through ATP synthesis, and pyroptosis susceptibility via NLRP3 inflammasome modulation

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