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Carnitine/acylcarnitine can reach almost all organs of the body to regulate metabolic functions and actively participate in communication and metabolic interactions between organs

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Since the enzyme encoded by the HMGCL gene is also involved in leucine catabolism, mutations in HMGCL also result in defects in metabolism of this amino acid and consequently leads to accumulation of leucine metabolites, 3-hydroxy-3-methylglutaric acid, 3-methylglutaconic acid, 3-methylglutaric acid, and 3-hydroxyisovaleric acid

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As for any single-centre study with a rather small sample size, further confirmation by an independent study is desirable, especially for the evaluation of the Xpert HCV VL FS test