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At high concentrations, Zn 2+ triggers full activation of IIb3 integrins and promotes platelet aggregation via the protein kinase C (PKC)/myosin light chain (MLC) phosphorylation pathway, whereas at low concentrations, Zn 2+ inhibits platelet activation and thrombus formation by enhancing prostacyclin I (PGI) signaling through the cyclic adenosine monophosphate (cAMP)/vasodilator-stimulated phosphoprotein (VASP) pathway (138140)
Metabolic efficiency signalling: Increased cellular energy expenditure readouts observed in structured preclinical systems

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