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Copper(II) ions serve as essential cofactors for numerous enzymes involved in tissue repair, including lysyl oxidase (collagen cross-linking), cytochrome c oxidase (mitochondrial energy production), and superoxide dismutase (antioxidant defense)

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doi: 10.1002/jmri.27530 24 BlairI

The toxicology findings are available for these, so fentanyl-positivity can give us a sense of what's happening, since nearly all of these eventually get adjudicated to be overdose deaths

Another study among post-treatment patients with objective memory impairment found a unique proteomic signature in the CSF with specific differentially increased complement cascade proteins (150)

Slower infusions may be used to improve comfort and tolerance, which increases clinician involvement