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Magnetic resonance spectroscopy In Experiment 2 to establish the effects of opioid withdrawal and NAC on CNS metabolism, we performed MRS scans on PND 6 and 7 prior to precipitated withdrawal (Pre-scans) and on PND 7 following the acute precipitated withdrawal, at 30 and 120 min (Post-scans)

2014;9(7):e100627

10.1016/0041-008X(91)90048-J 169 SairamT.ShanmugamG.NarasimhanM.SubramanianM.PatelA

p = 0.09)

For researchers concerned about cardiovascular risk, practical strategies to minimize TMAO production include supporting a healthy gut microbiome through prebiotic and probiotic use, monitoring TMAO levels if testing is available, and keeping total levocarnitine exposure within studied safety ranges

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