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2003 Oct;26(10):950-5

Notably, all these studies included only subjects with normal liver enzymes and no pre-existing liver disease or other confounding factors, further emphasizing the pivotal role of UCB increase

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As GPX4 is entirely dependent on GSH to neutralize toxic lipid peroxides, the depletion of GSH directly weakens the cell's most critical line of defense against ferroptosis (105)