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A 2015 paper in Nature Scientific Reports identified that gut microbiota actually convert berberine into dihydroberberine (DHB) in the intestinal wall, and it's the DHB that gets absorbed and then converts back to berberine in the bloodstream

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Recent developments in the significance and therapeutic relevance of neuroactive steroids--Introduction to the special issue

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

doi: 10.1073/pnas.1912012117

In: Goldman L, Schafer AI, (eds)
