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Ag120 (ivosidenib) is a compound that targets tumor cells by inhibiting the production of 2-HG mediated by IDH1mt (Radoul et al., 2021)

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[31] In response to the accumulation of the hazardous metabolic byproducts of aerobic respiration, biological systems evolved various strategies to counteract O 2 toxicity

2023;133:e165654

Meta-analysis of clinical metabolic profiling studies in cancer: challenges and opportunities

Studies showed that even in euthyroid individuals (defined as a TSH level in the upper half of the normal range), advanced liver disease has been associated with increased conversion of fT4 to inactive metabolite-reverse-triiodothyronine (rT3) in the liver, at the expense of DIO1-mediated conversion to the active metabolite-fT3 [19,20,21]