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The Del allele in this polymorphism is linked to a reduction in promoter activity which can result in decreased synthesis of the SOD1 enzyme, compromising the its ability to neutralize O 2 - radicals ( SOD1 gene polymorphisms extend to various diseases such as heart failure, cancer, diabetes, Downs syndrome, and amyotrophic lateral sclerosis owing to their roles in altered redox signaling

KI was used to determine hydrogen peroxide 78

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