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The instinct that a bigger dose means a bigger effect is the single most common design mistake with this class of peptide

PMID: 36163805

critical information on tissue penetration, metabolic half-lives, and clearance pathways is largely absent from the literature, undermining the ability to predict therapeutic windows or potential toxicities

666,667 PDK1 inhibits the activity of the PDH complex through phosphorylation, reducing the oxidation of pyruvate to acetyl-CoA in the Krebs cycle and increasing lactate production

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