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10.1093/alcalc/35.4.351 10 BondaD

doi: 10.1016/j.febslet.2005.12.046

Hyperglycemia causes pericyte damage, endothelial cell dysfunction, and basement membrane thickening in retinal vessels, leading to disruption of the blood-retinal barrier (108)

While other small studies have tested supplements with mixed results, screening for deficiencies and discussing supplementation with a healthcare provider may be worthwhile

The four-week hold per step is not arbitrary it matches the interval at which GI adverse events subside as the gut adapts

People with high levels of oxidative stress may potentially deplete their glutathione levels during the night