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The intrinsic pathway involves mitochondrial release of pro-apoptotic factors (apoptogens), such as cytochrome c and apoptosis-inducing factor (AIF), from the intermembrane space and antiapoptotic Bcl-2 family members (Bcl-2, Bcl-XL) that prevent the apoptosis-associated release of apoptogens (277, 319)

[DOI] [PMC free article] [PubMed] [Google Scholar] [240].Kwon HS, Koh SH, Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes, Transl Neurodegener 9(1) (2020) 42

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It may also be linked to other benefits and could aid in the treatment of conditions such as depression and nonalcoholic fatty liver disease (NAFLD)

Backpropagating action potentials trigger dendritic release of BDNF during spontaneous network activity