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Known Modulating Factors Modulating factors (MFs) may alter the shape of the response-response function that describes the quantitative relationship between two KES, thus having an impact on the progression of the pathway or the severity of the AO.The evidence supporting the influence of various modulating factors is assembled within the individual KERs

For example, combining alcohol feeding with a high-fat diet (with fat accounting for 25% of the caloric intake) in rats for 30 days can lead to significant liver fibrosis (Lamas-Paz et al., 2018)

Author Contributions Conceptualization, B.B., D.E.L

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Leukemia and Lymphoma 4:111-116, 1991

Lancet 383 , 11551167, doi: 10.1016/S0140-6736(13)60680-7 (2014)