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In their meta-analysis, Chiu et al
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production
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Dec 10 2015;528(7581):262-266
However, when the integrity of the intestinal barrier is damaged, the submucosal immune cells are exposed to bacteria, dietary antigens and autoantigens, which can result in adverse immune activation or tolerance response failure, leading to autoimmune diseases [79]
Those using higher doses of lithium orotate should always consult with a medical professional
