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Development of tridentate iron chelators: from desferrithiocin to ICL670

Vitamin B12 is necessary for the production of red blood cells, which help carry oxygen throughout the body

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We propose testing intralesional or intraperitoneal depot systems, as well as nanoparticle and liposomal carriers engineered to concentrate drug within pelvic lesions while limiting distribution to hematopoietic and hepatic tissues (9799)

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Using codon-randomizing mutagenesis to generate a clone library bearing nearly 80% of all possible amino acid changes, we measured the functional consequences of CBS variation by measuring the effects of selection on allele frequencies during a competitive yeast complementation assay using next-generation sequencing